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KMID : 0061119830110000145
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Bulletin of the Clinical Research Institute
1983 Volume.11 No. 0 p.145 ~ p.145
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Pattern of Oral Desensitization In DNCB Presensitized Guinea Pigs
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Nam Tae-Chung
Houh Won
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Abstract
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The pattern of 2 4 dinitrocholorobenzene oral desensitization and its antigenic specificity were studied in guinea pigs. In search of antigenic specificity of DNCB oral desensitization, animals were fed oxaxolone (4-ethoxymethylene-2-phenyl-oxazol-5-one) in a DNCB presensitized group and conversely, DNCB fed in an oxazolone presensitized group. For the experiment studied for the pattern of oral desensitization, guines pigs were initally sensitized to DNCB and followed by feeding of DNCB for 6 days, and challenged on the 13th, 21st, 29th, 37th and 45th day after the sensitization.
1. Oxazolone feeding in DNCB presensitized guinea ;pigs had no effect on the development of the fully responsive DNCB contact sensitivity (72.85%) and DNCB feeding lift no effect on the development of oxazolone contact sensitivity (79.37%). However, oxazolone feeding in DNCB presensitized guinea pigs and DNCB feeding in oxazolone presensitized guinea pigs resulted in oxazolone and DNCB oral tolerance (44.44%, p < 0.01 & 42.06%, p < 0.01).
2. The effect of desensitization appeared even one day before the completion of 6 days´ feeding and the efficacy lasted for about 30 days´ feeding and the efficacy lasted for about 30 days, which was attributed to the natural waning of contact sensitivity.
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